Planta Med 2011; 77 - PG87
DOI: 10.1055/s-0031-1282571

The Constituents from the Stem of Clausena lansium and their Bioactivities

T Wu 1, D Shen 1, C Chao 1, H Chan 1, W Lin 2, K Lee 3, T Thang 4
  • 1Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan; College of Pharmacy and Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40402, Taiwan
  • 2College of Pharmacy and Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40402, Taiwan
  • 3Natural Products Research Laboratories, Division of Medicinal Chemistry and Natural Products, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599–7568, USA
  • 4Department of Chemistry, Vinh University, Vinh City, Vietnam

Two new glycosides, clausenosides A (1) and B (2) and three new carbazole alkaloids, clausenaline A (3), claulamine A (4) and claulamine B (5), together with fifty known compounds were isolated from the stem of Clausena lansium Skeels. Their structures were determined by spectroscopic methods, including CD spectroscopy and 1D and 2D NMR spectra. Compound 4 has an 1-oxygenated carbazole framework with a rare 2,3-lactone ring. Compound 5 represents the first acetal carbazole alkaloid, of which the absolute configuration was determined by Mosher's method. The cytotoxicity of compounds 3-6 against a limited panel of cancer cell lines and the anti-inflammatory activity of 8-27 were evaluated.

Figure 1: Structures of compounds 1–5 from the stem of Clausena lansium

Acknowledgement: The authors are grateful for financial support from the National Science council of Republic of China awarded to T.-S. W. Thanks are also given to Associate Prof. Vu Xuan Phuong (Institute of Ecology and Biological Resources, Vietnamese Academy of Science and Technology). This study was supported in part by Taiwan Department of Health Clinical Trial and Research Center of Excellence (DOH 100-TD-B-111–004).