Planta Med 2011; 77 - PG86
DOI: 10.1055/s-0031-1282570

Lavandulifolioside B and Allomonomelittoside; two new glycosides from Stachys lavandulifolia Vahl

MR Delnavazi 1, A Delazar 2, M Mojarrab 2, S Sarker 3
  • 1Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  • 2Department of Pharmacognosy, Faculty of Pharmacy, Tabriz university of Medical Sciences, Tabriz, Iran
  • 3The School of Pharmacy, University of London, 29–39 Brunswick Square, United Kingdom

The genus Stachys (lamiaceae), consists about 200–300 species widespread throughout the world (1). In Iran, 34 species of this genus are present, including Stachys lavandulifolia Vahl (2). This species widely distributed in different regions of Iran and is known as the names of „Tuklidjeh“ and „Chaaye Koohi“. In Iranian folk medicine, decoction of aerial parts of S. lavandulifolia is used in painful and inflammatory gastrointestinal disorders (3). anxiolytic and sedative effects of this species also are known in traditional medicine when use as tea (4). in previous phytochemical studies two phenylethanoid glycosides; Acteoside and Lavandulifolioside have been reported from this plant (5). In continuation of our phytochemical studies on medicinal plants from Iran we now report three known phenylethanoid glycosides; Acteoside, Lavandulifolioside, leucosceptoside A and two new compounds; 4, 3',4' trimethoxy lavandulifolioside and one iridoid glycoside, 5-O-β allopyranosyl monomelittoside that were named lavandulifolioside B and allomonomelittoside respectively. These five glycosides were isolated from methanolic extract's Sep-pak fractions by using semi-preparative reversed-phase HPLC and its structures were elucidated by 1D-NMR and 2D-NMR spectroscopic techniques, and also by comparison of experimental data with literature data. Previous reports have indicated that phenylethanoid and iridoids possess anti-inflamatory, antioxidant and analgesic properties, thus it is reasonable to assume that these compounds can be responsible for traditional medicine uses and pharmacological effect of S. lavandulifolia.

References: 1- Rechinger KH, Hedge IC, (1982) Flora Iranica, Vol. 150. Akademiche Druck Verlagsanstalt, Graz, Austria, pp. 360–361.

2- Mozaffarian V, (1996) A Dictionary of Iranian Plant Names. Farhang Moaser, Tehran, Iran, p.522.

3- Zargari A (1990) Medicinal Plants. Vol 4. Tehran University Publications, Tehran, Iran, p.238.

4- Amin G (1991) Popular Medicinal Plants of Iran. Iranian Research Institue of Medicinal Plants, Tehran, Iran, p.80.

5- Basaran A et al. (1988). Helv Chim Acta 71: 1483–1490.