Terpenoids from the Root of Salvia hypoleuca Benth

The genus Salvia comprises nearly 900 species and is one of the largest members of the lamiaceae family.

Fifty eight species of this genus are found in Iran, 17 species of them are endemic.

In this study, the roots of Salvia hypoleuca Benth., were collected at flowering stage from Tehran province (Iran) and dried at room temperature, in shade. Dried plant materials were cut into small pieces and extracted with ethyl acetate by percolation method. Three sterols, sitosteryl oleate, sitosterol and stigmasterol, two diterpenoids, manool and 7α-acetoxy royleanone and five triterpenoids, ursolic acid, oleanolic acid, 3-epicorosolic acid, 3-epimaslinic acid and coleonolic acid, were isolated and purified by column chromatography (silicagels normal and reverse phases, Sephadex LH20). The structures of these compounds were identified by spectroscopic methods including ¹H-NMR, ¹³C-NMR, DEPT, HSQC, HMBC and H-H COSY. These compounds have been reported for the first time from Salvia hypoleuca of which coleonolic acid has not been previously reported from the genus Salvia.

Keywords: Lagochilus cabulicus, flavonoid, chromatography, spectroscopy

Acknowledgement: This research was supported by the Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences.