Planta Med 2011; 77 - PG67
DOI: 10.1055/s-0031-1282551

A New Guaianolide from the aerial parts of Centaurea pannonica (Heuffel) Simonkai

T Milosevic 1, C Gousiadou 3, D Muratspahic Pavlovic 2, S Solujic 1, H Skaltsa 3
  • 1Department of Chemistry, Faculty of Science, University of Kragujevac, Radoja Domanovica 12, 34000 Kragujevac, Serbia;
  • 2Department of Biology, Faculty of Science, University of Kragujevac, Radoja Domanovica 12, 34000 Kragujevac, Serbia;
  • 3Department of Pharmacognosy, School of Pharmacy, University of Athens, Panepistimiopolis, Zografou, 157 71, Athens, Greece

Centaurea is a complex genus of about 500 species belonging to the Asteraceae family [1]. Sesquiterpene lactones are the main chemical taxonomic markers of the genus [2,3]. Some members of this genus are used in folk medicine [4]. In the present study, we report the main compounds isolated from Centaurea pannonica (Heuffel) Simonkai, a taxon belonging to the section Jacea. The plant was collected in Šumadija region-Serbia, on September 2008. The aerial parts were extracted according to the Bohlmann isolation method, slightly modified [5]. One new naturally occurring sesquiterpene lactone (Fig.1), six known guaianolides, namely babylin A, chlorohyssopifolin C, chlororepdiolide, repdiolide, janerin, 19-deoxyjanerin and three known lignans arctigenin, matairesinol, arctiin were isolated by repeated CC and RP18-HPLC. The structure of the isolated compounds were elucidated by spectroscopic methods, particularly high-field NMR spectroscopy (1H-NMR, 1H-1H COSY, HSQC, HMBC). So far, the presence of guaianolides is characteristic for the taxa of the section Jacea [6, 7].

Figure 1

Acknowledgement: Greek foundation of Scholarships (IKY) and Ministry of Science, Republic of Serbia (project III 43004).

References: 1. Mabberley DJ (1997) The Plant Book. Cambridge University Press. Cambridge.

2. Djeddi S et al. (2008) Biochem Syst Ecol 36: 336–339.

3. Bruno M et al. (2005) Biochem Syst Ecol 33: 817–825.

4. Platéarius (1986) Le livre de simples médecines. Ed. Ozalid et Textes Cardinaux. Paris.

5. Bohlmann F et al. (1984) Phytochemistry 23: 1979–88.

6. Gonzalez AG et.al. (1974) Phytochemistry 13: 1193–1197.

7. Gonzalez AG et.al. (1978) Can J Chem 56: 491–494.