A New Guaianolide from the aerial parts of Centaurea pannonica (Heuffel) Simonkai
Centaurea is a complex genus of about 500 species belonging to the Asteraceae family . Sesquiterpene lactones are the main chemical taxonomic markers of the genus [2,3]. Some members of this genus are used in folk medicine . In the present study, we report the main compounds isolated from Centaurea pannonica (Heuffel) Simonkai, a taxon belonging to the section Jacea. The plant was collected in Šumadija region-Serbia, on September 2008. The aerial parts were extracted according to the Bohlmann isolation method, slightly modified . One new naturally occurring sesquiterpene lactone (Fig.1), six known guaianolides, namely babylin A, chlorohyssopifolin C, chlororepdiolide, repdiolide, janerin, 19-deoxyjanerin and three known lignans arctigenin, matairesinol, arctiin were isolated by repeated CC and RP18-HPLC. The structure of the isolated compounds were elucidated by spectroscopic methods, particularly high-field NMR spectroscopy (1H-NMR, 1H-1H COSY, HSQC, HMBC). So far, the presence of guaianolides is characteristic for the taxa of the section Jacea [6, 7].
Acknowledgement: Greek foundation of Scholarships (IKY) and Ministry of Science, Republic of Serbia (project III 43004).
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