New labdane-type diterpenoids and anti-inflammatory constituents from the rhizome of Hedychium coronarium
Hedychium coronarium J.Koenig (Zingiberaceae) is a terrestrial epiphytic herb, which is distribution in India, Malaysia, Vietnam, southern China and Taiwan . Two new labdane-type diterpenoids, hedychicoronarin (1) and peroxycoronarin D (2), together with eleven known compounds, including calcaratarin (3), (+)-coronarin A (4), coronarin D (5), coronarin D methyl ether (6), (E)-labda-8(17),12-diene-15,16-dial (7), ergosta-4,6,8(14),22-tetraen-3-one (8), β-sitostenone (9), stigmasta-4,22-dien-3-one (10), oleic acid (11), stearic acid (12), and palmitic acid (13) have been isolated from the rhizomes of Hedychium coronarium. The structure of new compounds 1 and 2 was determined through spectral analyses including extensive 2D NMR data. Among the isolates, calcaratarin (3), coronarin A (4), (E)-labda-8(17),12-diene-15,16-dial (7), and oleic acid (11) exhibited potent inhibition (IC50 <6.17µg/mL) against fMLP-induced superoxide production and elastase release.
Acknowledgement: This research was supported by grants from the National Science Council of the Republic of China (NSC 95–2320-B-127–001-MY3 and NSC 98–2320-B-127–001-MY3), awarded to Prof. J.-J. Chen.
References: 1. Wang J C et al. (2000) 'Zingiberaceae' in 'Flora of Taiwan', 2nd edn., Editorial Committee of the Flora of Taiwan, Taipei, Taiwan, Vol. 5, p.707–724.