Planta Med 2011; 77 - PG34
DOI: 10.1055/s-0031-1282518

New skeleton polyacetylene ferulic acid conjugates from Notopterygium incisum

X Liu 1, O Kunert 2, A Schinkovitz 1, N Fakhrudin 3, E Heiss 3, A Atanasov 3, V Dirsch 3, R Bauer 1
  • 1Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Karl-Franzens-Universität Graz, 8010 Graz, Austria
  • 2Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Karl-Franzens-Universität Graz, 8010 Graz, Austria
  • 3Department of Pharmacognosy, University of Vienna, 1090 Vienna, Austria

In our search for natural products activating PPAR-gamma we have isolated three polyacetylene ferulic acid conjugates (1-3) from the underground parts of Notopterygium incisum Ting ex H. T. Chang (Qiang Huo), in addition to previously isolated polyene-yne derived compounds.1,2 Their structures were elucidated by NMR and MS. Compound 1 is formed by an ester bond, while compound 2 and 3 represent two new skeletons. Pharmacological evaluation of the isolated compounds is in progress.

Figure 1: structures of polyacetylene ferulic acid conjugates from N. incisum.

Acknowledgement: We gratefully acknowledge the funding provided by the Austrian Science Fund (FWF) within project NFN S 10705-B13.

References: 1. Liu X et al. (2011) Planta Med in preparation

2. Blunder M et al. (2011) Planta Med in preparation