New skeleton polyacetylene ferulic acid conjugates from Notopterygium incisum
In our search for natural products activating PPAR-gamma we have isolated three polyacetylene ferulic acid conjugates (1-3) from the underground parts of Notopterygium incisum Ting ex H. T. Chang (Qiang Huo), in addition to previously isolated polyene-yne derived compounds.1,2 Their structures were elucidated by NMR and MS. Compound 1 is formed by an ester bond, while compound 2 and 3 represent two new skeletons. Pharmacological evaluation of the isolated compounds is in progress.
Acknowledgement: We gratefully acknowledge the funding provided by the Austrian Science Fund (FWF) within project NFN S 10705-B13.
References: 1. Liu X et al. (2011) Planta Med in preparation
2. Blunder M et al. (2011) Planta Med in preparation