Planta Med 2011; 77 - PG25
DOI: 10.1055/s-0031-1282509

Chemodiversity of Pentadesma grandifolia (Clusiaceae) from Cameroon

KM Valant Vetschera 1, GL Djoufack Nwabouloun 1, L Brecker 2
  • 1Department of Systematic and Evolutionary Botany, University of Vienna, Vienna, Austria
  • 2Institute of Organic Chemistry, University of Vienna, Vienna, Austria

Within the family Clusiaceae, the genus Pentadesma is represented by three species only, which are distributed in the tropical regions of Africa and America. Pentadesma grandifolia Baker f. is used in African folk medicine, and the roots and stem bark are applied to treating fever and malaria in the western part of Cameroon [1]. Xanthones, biflavanoids and triterpenoids are the major secondary metabolites of this genus as reported recently [1]. A new glycosidic biflavonoid and a further xanthone derivative were identified now from the same accession originating from Cameroon [1]. Profiling of different plant organs was done both by TLC and HPLC, and isolated structures were identified on basis of 13C NMR, 1H NMR, HRMS and ESI-MS. Structure elucidation and the distribution of isolated compounds in different parts of the plant will be presented. Tests for antifungal activity were performed by bio-autography on TLC against spore suspensions of Cladosporium sphaerospermum. The significance of bioactivity results and reported bioactivities of Pentadesma compounds are shortly discussed.

Acknowledgement: The financial support of OEAD for G. L. Djoufack is gratefully acknowledged.

References: 1. Djoufack Nwabouloun GL et al. (2010) Nat Prod Commun 5: 1055–1060