Triterpenoids and Flavonoids from Pavetta corymbosa

AA Ahmadu; A Agunu; P Magiatis

doi:10.1055/s-0031-1282508

Planta Medica, Inhaltsverzeichnis

Triterpenoids and Flavonoids from Pavetta corymbosa

AA Ahmadu ¹, A Agunu ², P Magiatis ³

¹Delta University, Wilberforce Island, Yenagoa-Nigeria, Department of Pharmaceutical and Medicinal Chemistry, Nigeria
²Ahmadu Bello University, Department of Pharmacognosy and Drug Development, Zaria, Nigeria
³University of Athens, Panespitimiopolis-Zografou, Greece, Department of Pharmacognosy and Natural Products Chemistry, Athens, Greece

Abstract

The genus Pavetta have long being used in ethnomedicine as anti-malaria, remedy for tuberculosis and for relieve of stomach pain (1).The literature does not report any phytochemical studies on Pavetta corymbosa (DC.) F.N. Williams.The dichloromethane and the ethyl acetate extracts were investigated for phytochemical constituents. Fractionation of the dichloromethane extract by Flash column chromatography, sephadex LH-20 and Preparative TLC afforded the trieterpenes: α-amyrin, lupenol, ursolic acid and a mixture (1:1) of β-sitosterol and stigmasterol, while the ethylacetate extract was fractionated over sephadex LH-20 to give the known flavonoids; quercetin, quercetin 7-O-rhamnoside and kaempferol. The structures were elucidated by NMR spectroscopy and compared with literature (2, 3, 4) and are reported here for the first time.

References: 1 Dalziel J.M and Hutchinson J (1955) Useful plants of West Africa. Crown Agents for Oversea Publication, London

2. Reynold WF et al. (1999)J Braz Chem Soc 10(3): 237–240

3. Ahmad SH and Nordin HL (1998) ARBEC II:1–6

4. Mabry T.J et al. (1970) The Systematic Identification of Flavonoids Springer-Verlag Publication, New York.