Planta Med 2011; 77 - PG17
DOI: 10.1055/s-0031-1282501

New type of polyacetylene sesquiterpenoid conjugates from Notopterygium incisum

X Liu 1, O Kunert 2, A Schinkovitz 1, N Fakhrudin 3, E Heiss 3, A Atanasov 3, V Dirsch 3, R Bauer 1
  • 1Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Karl-Franzens-Universität Graz, 8010 Graz, Austria
  • 2Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Karl-Franzens-Universität Graz, 8010 Graz, Austria
  • 3Department of Pharmacognosy, University of Vienna, 1090 Vienna, Austria

Qiang Huo, the dried rhizome and root of both Notopterygium incisum Ting ex H. T. Chang and N. forbesii Boiss. (Umbelliferae) are used widely in China for treating cold, and inflammatory diseases. Peroxisome Proliferator Activated Receptor gamma (PPAR-gamma) is involved in inflammatory processes, and has become an important pharmacological target.1 From the dichloromethane extracts of the underground parts of Notopterygium incisum, we have obtained through bio-guided isolation, a series of falcarindiol derivatives with significant PPAR-gamma agonistic activity.2 In addition, we have isolated eight polyacetylene derivatives (1-8), which were identified by NMR as unique polyacetylenes fused with sesquiterpenoids. They are a second type of polyacetylene adducts connected through an ether bond, besides previously reported coumarin adducts.3,4 The sesquiterpenoid moiety of 5 and 6 is reported for the first time.

Figure 1. structures of polyacetylene sesquiterpenoid conjugates from N. incisum.

Acknowledgement: We gratefully acknowledge the funding provided by the Austrian Science Fund (FWF) within project NFN S 10705-B13.

References: 1. Schmidt MV et al. (2010) Scientific World Journal 10: 2181–97

2. Blunder M. et al. (2011) Planta Medin preparation

3. Furumi K et al. (1998) Bioorg Med Chem Lett 8: 93–6.

4. Fujioka T et al. (1999) Chem Pharm Bull 47: 96–100.