Investigation of Flavonoidal Constituents and Hepatoprotective Activity of Myoporum laetum
Myoporum laetum G.Forst. (Myoporaceae) is an evergreen ornamental shrub and it flowers from May to June .Fractionation and isolation of the butanol extract of Myoporum laetum yielded five major flavonoids, luteolin 4'-O-α-L rhamnoside, 5-methoxy-luteolin 7-O-β-D-arabinoside, 5'-hydroxy-luteolin 7-O-β-D-glucoside (tricetin 7-O-β-D-glucoside), luteolin and apigenin. Their structures were determined by chromatographic and spectroscopic methods. The hepatoprotective and antioxidant activities of the butanol extract against liver injury induced by repeated doses of the profenofos as hepatotoxicant were investigated. Oral supplementation of butanol extract to profenofos treated animals successfully modulated the hepatotoxicant induces deviation in the liver function markers (liver oxidative and antioxidant markers) indicating its potential hepatoprotective and antioxidant abilities.
References: 1. Blackburne et al. (1972) Aust J Chem 25: 1787–96.