Anti-inflammatory Evaluation of Ageratum conyzoides L. Leaves

NE Awad; HA Kassem; AA Matloub; Z Elkhyat; AM Elfeky

doi:10.1055/s-0031-1282457

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Planta Med 2011; 77 - PF69
DOI: 10.1055/s-0031-1282457

Anti-inflammatory Evaluation of Ageratum conyzoides L. Leaves

NE Awad ¹, HA Kassem ², AA Matloub ¹, Z Elkhyat ³, AM Elfeky ¹

¹Pharmacognosy Department, National Research Center, Dokki, Cairo, Egypt
²Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Alkasr Alani, Cairo, Egypt
³Medical biochemistry Department, National Research Center, Dokki, Cairo, Egypt

Congress Abstract

Alcohol extract (70%) as well as successive extracts of the air dried powdered Ageratum conyzoides leaves have been evaluated for their anti-inflammatory and chemical constitution. All extracts showed high significant anti-inflammatory activities against carragenan induce edema. Moreover, crude extract and ethyl acetate exhibited good anti-inflammatory activity against cytokine interlukin (1L)-6 than the other extracts. Quantitative and qualitative estimation of the total flavonoid, steroidal, triterpenoidal, protein and carbohydrate contents of 70% alcohol extract were determined. The mucilage of crude extract was isolated, identified using HPLC and re-evaluated for their anti-inflammatory activity. The free and glycosidal flavonoids of ethyl acetate extract were isolated. Kaempferol, p- hydroxyl benzoic acid, quercetin-3-O-rhamnopyranoside and quercetin-3,7- diglucopyranoside were isolated from ethyl acetate extract. The isolated flavonoidal fractions and compounds are evaluated for anti-inflammatory activity. The glycosidal flavonoid fractions proved greater anti-inflammatory effect than the isolated compounds.