Effects of Angelicae Gigantis Radix (AGR) on Polycystic Ovary induced by Estradiol Valerate in rats
Angelicae Gigantis Radix (AGR) is the most frequently used medicinal plats for patients with gynecological problems, especially pregnancy (1,2). This study was designed to investigate the effects of (AGR) on Polycystic Ovary (PCO) induced by Estradiol valerate (EV) in female rats. We investigated the effects of AGR on Changes in body weights and food and water uptake for 5 weeks. In addition, we examined the effects on ovary weights. Finally, we also observed histopathological changes in PCO rats. In our results, AGR administration group restored ovary/body weight ratio to normal levels, which were lowered by induction of PCO (3). In histopathological observation, formation of cysts was suppressed in AGR group compared with non-treated PCO group). In conclusion, these results suggest that AGR can be used for patients with PCO to prevent formation of cystic follicles and malfunction of ovary.
References: 1. Yoo DL (2001)J Oriental Gynecology 14(1): 453–460.
2. Shin YW et al. (2003)J Oriental Gynecology 16(4):180–188.
3. Farookhi R, Hemmins R, Brawer J R (1985) Biology of Reproduction 32: 530–540.