Planta Med 2011; 77 - PC5
DOI: 10.1055/s-0031-1282309

Efficacy of Punica granatum extract on in vitro and in vivo control of Trichomonas vaginalis

GT El Sherbini 1, KM Ibrahim 2, ET El Sherbini 3, NM Abdel Hady 4, TA Morsy 5
  • 1Department of Parasitology, October 6 university Cairo, Egypt.
  • 2Department of Zoology, Al-Azahar university, Cairo, Egypt.
  • 3Department of Zoology, El Nahda university, Beni Sweif, Egypt.
  • 4Department of Pharmacognosy, Al-Azahar university, Cairo, Egypt.
  • 5Department of Parasitology, Ain-Shams, Cairo, Egypt.

Trichomoniasis vaginalis is now an important worldwide health problem. Metronidazole has so far been used in treatment, but the metronidazole resistant strains and unpleasant adverse effects have been developed. Treatment of patients with metronidazole refractory vaginal trichomoniasis constitutes a major therapeutic challenge and treatment options are extremely limited. The last 7 years have seen over seven times as many publication indexed by Medline dealing with pomegranate (Punica granatum L.) than in all the years preceding them, because of this, and the virtual explosion of interest in pomegranate (Roman) was in vitro investigated for its efficacy against T. vaginalis on Diamond media. Besides, infected women (18/20) who accepted to be treated with P. granatum juice were completely cured and followed- up for two months. The anti-trichomoniasis vaginalis activity of P. granatum extract (in vitro and in vivo) gave very promising results.

Acknowledgement: The authors thank all the participants who shared their time for working on this study.

References: 1. Abdel Hady NM, El- Sherbini GT, Morst TA (2008)J Egypt Soc Parasitol 38(3): 1024–5

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