Bioavailability and pharmacokinetic of the Algerian propolis constituent naringenin in rats after oral administration

Till now, a limited number of pharmacokinetics and bioavailability of propolis compounds studies have been performed. So, the absorption of orally administered Naringenin, an active component of Algerian propolis (14.2%), in rats has been studied to evaluate its pharmacokinetics and bioavailability in vivo in comparison with those of a standard solution of naringenin. Rats were given 100mg/kg of body weight of aqueous propolis extract or 14.2mg/kg of naringenin. Blood was collected from the retro-orbital sinus. Naringenin was quantified by coulometric detection using HPLC-UV system. In vivo pharmacokinetic study of propolis extract shows a good and rapid absorption from the gastrointestinal tract and reveal a high bioavailability. The serum concentration of naringenin from propolis was 17.45 nmol/ml, T_max=60min, the total clearance 9.35ml/mn, the area under the curve (AUC0–360) 32821 nmol.mn/ml, and the volume of distribution (Vd) was 1949.15ml. Compared to the standard naringenin, Algerian propolis constituent naringenin shows a better bioavailability and diffusion that may explain the antioxidant effects flavonoids extracted from propolis.

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