Planta Med 2011; 77 - SL71
DOI: 10.1055/s-0031-1282194

Biological and chemical study of two Indonesian marine endophytic fungi

K Tarman 1, GJ Palm 2, K Wende 3, U Lindequist 3
  • 1Department of Aquatic Product Technology, Bogor Agricultural University, Jl. Agathis 1, 16680 Bogor, Indonesia
  • 2Institute of Biochemistry, Greifswald University, Felix-Hausdorff-Strasse 4, 17489 Greifswald, Germany
  • 3Institute of Pharmacy, Greifswald University, Friedrich-Ludwig-Jahn-Strasse 17, 17489 Greifswald, Germany

In the search for biologically active natural products from Indonesian marine sources two strains of marine endophytic fungi could be isolated from the marine red alga Kappaphycus alvarezii. One strain (KT 30) could be identified as Xylaria psidii, the other one (KT 31) remains sterile and could not be identified till now. Ethylacetate extracts from the culture medium displayed considerable cytotoxic activity against a urinary bladder carcinoma cell line with IC50 values of 4 and 1.5µg/ml, respectively. Both strains were also obviously active to inhibit the growth of fish and human pathogenic microorganisms. Most remarkable is the strong antimicrobial activity of ethylacetate extracts against the gram-negative bacteria Pseudomonas aeruginosa, Escherichia coli, Vibrio anguillarum and Aeromonas salmonicida. A new cyanomethoxy benzoic acid derivative was isolated from X. psidii KT30 and a new quinone derivative from the algicolous fungus KT31. Besides, cytochalasin B was detected for the first time in X. psidii.

Keywords: Indonesian marine fungi, algicolous, antifungal, cytotoxic

Acknowledgement: We thank PD Dr. Marc Stadler (InterMedDiscovery, Dortmund, Germany) for identification of the Xylaria species.