Skull Base Rep 2011; 1(2): 111-114
DOI: 10.1055/s-0031-1280738
© Thieme Medical Publishers

Aggressive Inverted Papilloma with Intracranial Invasion and Short Malignization Time

Peter Valentin Tomazic1 , Heinz Stammberger1 , Walter Habermann1 , Christoph Schmid1 , Wolfgang Koele1 , Michael Mokry2 , Verena Gellner2 , Alfred Beham3
  • 1Department for General Otolaryngology, Head and Neck Surgery, Medical University Graz, Graz, Austria
  • 2Department of Neurosurgery, Medical University Graz, Graz, Austria
  • 3Institute of Pathology, Medical University Graz, Graz, Austria
Further Information

Publication History

Publication Date:
09 June 2011 (online)


Inverted papillomas (IP) are considered benign lesions with a prevalence up to 4% among all sinunasal tumors; however, invasive growth and varying tendency for malignization are reported in literature. We report the case of a 69-year-old woman suffering from a large, aggressively growing IP invading the orbit, skull base, and frontal lobe of the brain. Within only 3 months' time the papilloma showed transformation into an invasive carcinoma, leaving surgical therapy in vain due to explosive recurrence. Intracranial and intraorbital expansion by IP is possible despite histology not showing signs of malignancy initially. In “regular” IP close endoscopic follow-up is mandatory to not overlook recurrence harboring malignancy.


Peter Valentin Tomazic, M.D. 

ENT-University Hospital Graz, Medical University Graz

Auenbruggerplatz 26/28, 8036 Graz, Austria

Email: [email protected]