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Planta Med 2011; 77(18): 2042-2046
DOI: 10.1055/s-0031-1280096
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Three New Phenolic Compounds from the Lichen Thamnolia vermicularis and Their Antiproliferative Effects in Prostate Cancer Cells

Jia Guo1 , 2 , Zhan-lin Li1 , 2 , Ao-li Wang1 , 2 , Xiao-qiu Liu2 , Jian Wang1 , 5 , Xin Guo3 , Yong-kui Jing4 , Hui-ming Hua1 , 2
  • 1Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, P. R. China
  • 2School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, P. R. China
  • 3School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, P. R. China
  • 4Department of Medicine, Mount Sinai School of Medicine, New York, NY, USA
  • 5School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, P. R. China
Further Information

Publication History

received February 22, 2011 revised June 17, 2011

accepted June 28, 2011

Publication Date:
27 July 2011 (online)

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Abstract

Three new phenolic compounds, thamnoliadepsides A (1), B (2), and thamnolic acid A (3), and seven known compounds, everninic acid (4), baeomycesic acid (5), β-orcinol (6), β-resorcylic acid (7), ethyl orsellinate (8), squamatic acid (9), and vermicularin (10), were isolated from the lichen Thamnolia vermicularis (Sw.) Ach. ex Schaerer. Their structures were determined based on spectroscopic analysis, including 2D-NMR experiments and HR-MS techniques. Compound 1 inhibited growth of prostate cancer cells and bonded to G-quadruplex DNA based on NMR determination.

Key words

Thamnolia vermicularis - Thamnoliaceae - depside - antiproliferative - G-quadruplex

Supporting Information

References

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Prof. Dr. Hui-ming Hua

Key Laboratory of Structure-Based Drug Design & Discovery
Ministry of Education
School of Traditional Chinese Materia Medica
Shenyang Pharmaceutical University

Box 49

Shenyang 110016

People's Republic of China

Phone: +86 24 23 98 64 65

Fax: +86 24 23 98 64 65

Email: huimhua@163.com

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