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Planta Med 2011; 77(18): 2023-2028
DOI: 10.1055/s-0031-1280087
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Sesquiterpenoids from the Resinous Exudates of Commiphora myrrha and Their Neuroprotective Effects

Jing Xu1 , Yuanqiang Guo1 , Yushan Li2 , Peng Zhao3 , Cuizhou Liu1 , Yonggang Ma1 , Jie Gao1 , Wenbin Hou4 , Tiejun Zhang4
  • 1College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, People's Republic of China
  • 2School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, People's Republic of China
  • 3Tianjin Children's Hospital, Tianjin, People's Republic of China
  • 4Tianjin Institute of Pharmaceutical Research, Tianjin, People's Republic of China
Further Information

Publication History

received May 3, 2011 revised June 16, 2011

accepted June 18, 2011

Publication Date:
09 August 2011 (online)

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Abstract

Ten new furanosesquiterpenoids, myrrhterpenoids A–J (1–10), together with eight known analogues (11–18), were isolated from the resinous exudates of Commiphora myrrha. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HRESIMS, 1D and 2D NMR) and by the ChemDraw 3D modeling using MM2. All isolated furanosesquiterpenes showed neuroprotective effects against MPP+-induced neuronal cell death in SH-SY5Y cells.

Key words

Commiphora myrrha - Burseraceae - furanosesquiterpene - neuroprotective effect

Supporting Information

References

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Dr. Yuanqiang Guo

College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research
Nankai University

94 Weijin Road

Tianjin 300071

People's Republic of China

Phone: +86 22 23 50 25 95

Fax: +86 22 23 50 25 95

Email: victgyq@163.com

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