Skull Base Rep 2011; 1(2): 095-098
DOI: 10.1055/s-0031-1276723
© Thieme Medical Publishers

Hepatoid Adenocarcinoma of the Anterior Skull Base: A Case Report

Rebecca Zener1 , Olga Gologan2 , Noah Sands1 , Anthony G. Zeitouni1
  • 1Department of Otolaryngology–Head and Neck Surgery, McGill University Health Center, Montreal, Quebec, Canada
  • 2Department of Pathology, McGill University Health Center, Montreal, Quebec, Canada
Further Information

Publication History

Publication Date:
11 April 2011 (online)


We report the first case of hepatoid adenocarcinoma of the skull base, as well as the first reported case in the head and neck region. Hepatoid adenocarcinoma is a rare, aggressive, extrahepatic malignancy with a distinct morphological similarity to hepatocellular carcinoma, in the absence of primary hepatic disease. A 45-year-old man presented with sinus headaches and retro-orbital pain and was found to have a nasopharyngeal mass on endoscopy and a large, destructive sinonasal mass extending intracranially on imaging. Histo- and cytopathological features were similar to hepatocellular carcinoma, and the cells were immunoreactive for α-fetoprotein, epithelial membrane antigen, periodic acid-Schiff, cytokeratin (CK)8/18, CK19, and S100.


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Anthony G ZeitouniM.D. M.Sc. 

Royal Victoria Hospital, 687 Pine Avenue West

E4.45, Montreal, Quebec, Canada, H3A 1A1