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DOI: 10.1055/s-0031-1275288
© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Flattened Circadian Cortisol Rhythm in Type 2 Diabetes
Publication History
received 27.01.2011
first decision 04.03.2011
accepted 07.03.2011
Publication Date:
06 April 2011 (online)
Abstract
Introduction: While altered cortisol concentrations have been observed in subjects with type 2 diabetes their circadian cortisol profile is unknown.
Patients and methods: Using a cross-sectional design, we studied 63 ambulatory individuals with type 2 diabetes and 916 non-diabetic control subjects of the Cooperative Research in the Region of Augsburg (KORA)-F3 study. Circadian cortisol profiles were derived from saliva cortisol concentrations, determined on a regular weekday upon wake-up (F0), as well as œ h (Fœ), 8 (F8) and 14 h (F14) after wake-up.
Results: Diabetic subjects exhibited a flattened circadian cortisol profile (rm-ANOVA: F[3,654]=3.41, p=0.02), with lower morning and higher afternoon and evening cortisol concentrations.
Conclusion: We observed a flattened circadian cortisol rhythm in subjects with type 2 diabetes, providing evidence for a specific HPA system dysfunction.
Key words
glucocorticoids - hypothalamic-pituitary-adrenal system - circadian rhythm
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Correspondence
F. LederbogenMD
Central Institute of Mental
Health
J5 68159 Mannheim
Germany
Phone: +49/621/1703 2402
Fax: +49/621/1703 1205
Email: florian.lederbogen@zi-mannheim.de