Exp Clin Endocrinol Diabetes 2011; 119(4): 218-220
DOI: 10.1055/s-0031-1275276

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Metabolic Effects of the Ingestion of Different Fructose Sources in Rats

C. J. C. S. Meirelles1 , L. A. Oliveira2 , A. A. Jordão1 , A. M. Navarro1
  • 1Postgraduation in Medical Sciences, Department of Medicine, Faculty of Medicine of Ribeirão Preto – USP
  • 2Postgraduation in Foods and Nutrition, Department of Foods, Faculty of Pharmaceutical Sciences of Araraquara – UNESP
Further Information

Publication History

received 16.09.2010 first decision 21.02.2011

accepted 03.03.2011

Publication Date:
04 April 2011 (online)


Introduction: Fructose is a simple carbohydrate that should be ingested in a restricted manner. However, current data suggest increased daily consumption of fructose which may lead to an increased incidence of diseases such as obesity, diabetes and co-morbidities associated with excess weight. Thus, the objective of the present study was to assess the effect of the ingestion of different fructose sources on weight gain, glycemia and serum triglyceride levels in rats.

Methods: The study was conducted on male Wistar rats divided into 5 groups according to the source and concentration of fructuse (ingested ad libitum in liquid form).

Results: Drink intake was increased and chow consumption was reduced in all groups compared to control (p<0.05). The animals of the groups receiving 10 and 20% fructose solutions showed increased triglyceride levels and the 20% group also showed weight gain. The exaggerate consumption of fructose promotes a reduced consumption of chow, an increase in serum triglyceride levels, and weight gain in some animals.



C. J. C. de Souza Meirelles

Department of Medicine

Faculty of Medicine of Ribeirão

Preto – USP. Av.

Bandeirantes 3900

CEP: 14049-900

Ribeirão Preto – SP


Phone: +55 16 3602-4547

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Email: clarissameirelles@usp.br