Semin intervent Radiol 2011; 28(1): 075-086
DOI: 10.1055/s-0031-1273942
© Thieme Medical Publishers

Management of Pleural Effusion, Empyema, and Lung Abscess

Hyeon Yu1
  • 1Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
Further Information

Publication History

Publication Date:
22 March 2011 (online)

ABSTRACT

Pleural effusion is an accumulation of fluid in the pleural space that is classified as transudate or exudate according to its composition and underlying pathophysiology. Empyema is defined by purulent fluid collection in the pleural space, which is most commonly caused by pneumonia. A lung abscess, on the other hand, is a parenchymal necrosis with confined cavitation that results from a pulmonary infection. Pleural effusion, empyema, and lung abscess are commonly encountered clinical problems that increase mortality. These conditions have traditionally been managed by antibiotics or surgical placement of a large drainage tube. However, as the efficacy of minimally invasive interventional procedures has been well established, image-guided small percutaneous drainage tubes have been considered as the mainstay of treatment for patients with pleural fluid collections or a lung abscess. In this article, the technical aspects of image-guided interventions, indications, expected benefits, and complications are discussed and the published literature is reviewed.

REFERENCES

  • 1 Light R W. Pleural Diseases. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2001
  • 2 Chung J, Perrot M D. Pleural effusion and empyema thoracis. In: Bope E T, Rakel R E, Kellerman R D, eds. Conn's Current Therapy 2010. 1st ed. Philadelphia: Saunders/ Elsevier; 2010: 263-265
  • 3 Light R W, Macgregor M I, Luchsinger P C, Ball Jr W C. Pleural effusions: the diagnostic separation of transudates and exudates.  Ann Intern Med. 1972;  77 (4) 507-513
  • 4 Sahn S A. State of the art. The pleura.  Am Rev Respir Dis. 1988;  138 (1) 184-234
  • 5 Miller E J, Idell S. Interleukin-8: an important neutrophil chemotaxin in some cases of exudative pleural effusions.  Exp Lung Res. 1993;  19 (5) 589-601
  • 6 Broaddus V C, Light R W. Pleural Effusion. In: Mason R J, Broaddus V C, Martin T R, et al, eds. Textbook of Respiratory Medicine. 5th ed. Philadelphia: Saunders/Elsevier; 2010: 1719-1763
  • 7 Bouros D, Plataki M, Antoniou K M. Parapneumonic effusion and empyema: best therapeutic approach.  Monaldi Arch Chest Dis. 2001;  56 (2) 144-148
  • 8 Schiza S, Siafakas N M. Clinical presentation and management of empyema, lung abscess and pleural effusion.  Curr Opin Pulm Med. 2006;  12 (3) 205-211
  • 9 Light R W. Parapneumonic effusions and empyema.  Clin Chest Med. 1985;  6 (1) 55-62
  • 10 Colins J D, Burwell D, Furmanski S, Lorber P, Steckel R J. Minimal detectable pleural effusions. A roentgen pathology model.  Radiology. 1972;  105 (1) 51-53
  • 11 Moskowitz H, Platt R T, Schachar R, Mellins H. Roentgen visualization of minute pleural effusion. An experimental study to determine the minimum amount of pleural fluid visible on a radiograph.  Radiology. 1973;  109 (1) 33-35
  • 12 Eibenberger K L, Dock W I, Ammann M E, Dorffner R, Hörmann M F, Grabenwöger F. Quantification of pleural effusions: sonography versus radiography.  Radiology. 1994;  191 (3) 681-684
  • 13 Feller-Kopman D. Ultrasound-guided thoracentesis.  Chest. 2006;  129 (6) 1709-1714
  • 14 Liu Y H, Lin Y C, Liang S J et al.. Ultrasound-guided pigtail catheters for drainage of various pleural diseases.  Am J Emerg Med. 2010;  28 (8) 915-921
  • 15 Bressler E L, Francis I R, Glazer G M, Gross B H. Bolus contrast medium enhancement for distinguishing pleural from parenchymal lung disease: CT features.  J Comput Assist Tomogr. 1987;  11 (3) 436-440
  • 16 Moulton J S, Benkert R E, Weisiger K H, Chambers J A. Treatment of complicated pleural fluid collections with image-guided drainage and intracavitary urokinase.  Chest. 1995;  108 (5) 1252-1259
  • 17 Keeling A N, Leong S, Logan P M, Lee M J. Empyema and effusion: outcome of image-guided small-bore catheter drainage.  Cardiovasc Intervent Radiol. 2008;  31 (1) 135-141
  • 18 Light R W, Rodriguez R M. Management of parapneumonic effusions.  Clin Chest Med. 1998;  19 (2) 373-382
  • 19 Moulton J S. Image-guided management of complicated pleural fluid collections.  Radiol Clin North Am. 2000;  38 (2) 345-374
  • 20 Light R W. Clinical practice. Pleural effusion.  N Engl J Med. 2002;  346 (25) 1971-1977
  • 21 Shinto R A, Light R W. Effects of diuresis on the characteristics of pleural fluid in patients with congestive heart failure.  Am J Med. 1990;  88 (3) 230-234
  • 22 Diacon A H, Brutsche M H, Solèr M. Accuracy of pleural puncture sites: a prospective comparison of clinical examination with ultrasound.  Chest. 2003;  123 (2) 436-441
  • 23 Thomsen T W, DeLaPena J, Setnik G S. Videos in clinical medicine. Thoracentesis.  N Engl J Med. 2006;  355 (15) e16
  • 24 Petersen W G, Zimmerman R. Limited utility of chest radiograph after thoracentesis.  Chest. 2000;  117 (4) 1038-1042
  • 25 Trachiotis G D, Vricella L A, Aaron B L, Hix W R. As originally published in 1988: Reexpansion pulmonary edema. Updated in 1997.  Ann Thorac Surg. 1997;  63 (4) 1206-1207
  • 26 Grogan D R, Irwin R S, Channick R et al.. Complications associated with thoracentesis. A prospective, randomized study comparing three different methods.  Arch Intern Med. 1990;  150 (4) 873-877
  • 27 Raptopoulos V, Davis L M, Lee G, Umali C, Lew R, Irwin R S. Factors affecting the development of pneumothorax associated with thoracentesis.  AJR Am J Roentgenol. 1991;  156 (5) 917-920
  • 28 Colice G L, Curtis A, Deslauriers J et al.. Medical and surgical treatment of parapneumonic effusions : an evidence-based guideline.  Chest. 2000;  118 (4) 1158-1171
  • 29 Shankar S, Gulati M, Kang M, Gupta S, Suri S. Image-guided percutaneous drainage of thoracic empyema: can sonography predict the outcome?.  Eur Radiol. 2000;  10 (3) 495-499
  • 30 Rahman N M, Maskell N A, Davies C W et al.. The relationship between chest tube size and clinical outcome in pleural infection.  Chest. 2010;  137 (3) 536-543
  • 31 Davies H E, Rahman N M, Parker R J, Davies R J. Use of indwelling pleural catheters for chronic pleural infection.  Chest. 2008;  133 (2) 546-549
  • 32 Pierrepoint M J, Evans A, Morris S J, Harrison S K, Doull I J. Pigtail catheter drain in the treatment of empyema thoracis.  Arch Dis Child. 2002;  87 (4) 331-332
  • 33 Dev S P, Nascimiento Jr B, Simone C, Chien V. Videos in clinical medicine. Chest-tube insertion.  N Engl J Med. 2007;  357 (15) e15
  • 34 Pollak J S, Burdge C M, Rosenblatt M, Houston J P, Hwu W J, Murren J. Treatment of malignant pleural effusions with tunneled long-term drainage catheters.  J Vasc Interv Radiol. 2001;  12 (2) 201-208
  • 35 Zimmerman L H. Pleural effusions. In: Goldstein R H, O'Connell J J, Karlinsky J B, eds. A Practical Approach to Pulmonary Medicine. Philadelphia: Lippincott-Raven; 1997: 195-205
  • 36 Grossi F, Pennucci M C, Tixi L, Cafferata M A, Ardizzoni A. Management of malignant pleural effusions.  Drugs. 1998;  55 (1) 47-58
  • 37 Tattersall M. Management of malignant pleural effusion.  Aust N Z J Med. 1998;  28 (3) 394-396
  • 38 Musani A I. Treatment options for malignant pleural effusion.  Curr Opin Pulm Med. 2009;  15 (4) 380-387
  • 39 Pollak J S. Malignant pleural effusions: treatment with tunneled long-term drainage catheters.  Curr Opin Pulm Med. 2002;  8 (4) 302-307
  • 40 Tremblay A, Michaud G. Single-center experience with 250 tunnelled pleural catheter insertions for malignant pleural effusion.  Chest. 2006;  129 (2) 362-368
  • 41 Thornton R H, Miller Z, Covey A M et al.. Tunneled pleural catheters for treatment of recurrent malignant pleural effusion following failed pleurodesis.  J Vasc Interv Radiol. 2010;  21 (5) 696-700
  • 42 Ohm C, Park D, Vogen M et al.. Use of an indwelling pleural catheter compared with thorascopic talc pleurodesis in the management of malignant pleural effusions.  Am Surg. 2003;  69 (3) 198-202 discussion 202
  • 43 Pien G W, Gant M J, Washam C L, Sterman D H. Use of an implantable pleural catheter for trapped lung syndrome in patients with malignant pleural effusion.  Chest. 2001;  119 (6) 1641-1646
  • 44 Davies C W, Gleeson F V, Davies R J. Pleural Diseases Group, Standards of Care Committee, British Thoracic Society . BTS guidelines for the management of pleural infection.  Thorax. 2003;  58 (Suppl 2) ii18-ii28
  • 45 Temes R T, Follis F, Kessler R M, Pett Jr S B, Wernly J A. Intrapleural fibrinolytics in management of empyema thoracis.  Chest. 1996;  110 (1) 102-106
  • 46 Zuckerman D A, Reed M F, Howington J A, Moulton J S. Efficacy of intrapleural tissue-type plasminogen activator in the treatment of loculated parapneumonic effusions.  J Vasc Interv Radiol. 2009;  20 (8) 1066-1069
  • 47 Davies C W, Traill Z C, Gleeson F V, Davies R J. Intrapleural streptokinase in the management of malignant multiloculated pleural effusions.  Chest. 1999;  115 (3) 729-733
  • 48 Maskell N A, Davies C W, Nunn A J First Multicenter Intrapleural Sepsis Trial (MIST1) Group et al. U.K. Controlled trial of intrapleural streptokinase for pleural infection.  N Engl J Med. 2005;  352 (9) 865-874
  • 49 Tokuda Y, Matsushima D, Stein G H, Miyagi S. Intrapleural fibrinolytic agents for empyema and complicated parapneumonic effusions: a meta-analysis.  Chest. 2006;  129 (3) 783-790
  • 50 Erasmus J J, Goodman P C, Patz Jr E F. Management of malignant pleural effusions and pneumothorax.  Radiol Clin North Am. 2000;  38 (2) 375-383
  • 51 Lee Y C, Baumann M H, Maskell N A et al.. Pleurodesis practice for malignant pleural effusions in five English-speaking countries: survey of pulmonologists.  Chest. 2003;  124 (6) 2229-2238
  • 52 Putnam Jr J B, Light R W, Rodriguez R M et al.. A randomized comparison of indwelling pleural catheter and doxycycline pleurodesis in the management of malignant pleural effusions.  Cancer. 1999;  86 (10) 1992-1999
  • 53 Shaw P, Agarwal R. Pleurodesis for malignant pleural effusions.  Cochrane Database Syst Rev. 2004;  (1) CD002916
  • 54 Mager H J, Maesen B, Verzijlbergen F, Schramel F. Distribution of talc suspension during treatment of malignant pleural effusion with talc pleurodesis.  Lung Cancer. 2002;  36 (1) 77-81
  • 55 Dryzer S R, Allen M L, Strange C, Sahn S A. A comparison of rotation and nonrotation in tetracycline pleurodesis.  Chest. 1993;  104 (6) 1763-1766
  • 56 Morrow L E, Jarrett J. Primary Lung Abscess. In: Bope E T, Rakel R E, Kellerman R D, eds. Conn's Current Therapy 2010. 1st ed. Philadelphia: Saunders/Elsevier; 2010: 266-267
  • 57 Stark D D, Federle M P, Goodman P C, Podrasky A E, Webb W R. Differentiating lung abscess and empyema: radiography and computed tomography.  AJR Am J Roentgenol. 1983;  141 (1) 163-167
  • 58 Mwandumba H C, Beeching N J. Pyogenic lung infections: factors for predicting clinical outcome of lung abscess and thoracic empyema.  Curr Opin Pulm Med. 2000;  6 (3) 234-239

Hyeon YuM.D. 

Clinical Assistant Professor, Vascular and Interventional Radiology, Department of Radiology, University of North Carolina at Chapel Hill

2016 Old Clinic, CB 7510, Chapel Hill, NC 27599-7510

Email: hyeon_yu@med.unc.edu

    >