Planta Med 2011; 77 - P_40
DOI: 10.1055/s-0031-1273569

A Phytochemical Study of Zygophyllum simplex L.

E Amin 1, 3, SS El-Hawary 2, MM Fathy 2, R Mohammed 1, IA Khan 3, 4, 5
  • 1Faculty of Pharmacy, Beni Suef University, Egypt
  • 2Faculty of Pharmacy, Cairo University, Egypt
  • 3National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, MS 38677, USA
  • 4Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
  • 5Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

In continuation of our work on Egyptian plants of the genus Zygophyllum, Zygophyllum simplex L. was chosen for the study. Z. simplex L. is one of the common species of the genus Zygophyllum growing in Egypt [1]. The plant growing in North Africa and Arabian region was reported to be used in the treatment of horny patches on the skin [2]. The current phytochemical study of the aerial parts of the plant has resulted in isolation and structural elucidation of seventeen compounds belonging to different chemical classes. The isolated compounds were identified as isorhamnetin (1), isorhamnetin-3-O-glucoside (2), isorhamnetin-3, 7-diglucoside (3), isorhamnetin-3-O-(6'-malonyl)glucoside (4), quercetin-3-O-glucoside (5), quercetin-3-O-(6''-malonyl) glucoside (6), vanillic acid(7), ferulic acid (8), p-hydroxy benzoic acid (9), p-hydroxy acetophenone (10), p-hydroxy acetophenone glucoside (11), androsin (12), adenine (13), thymidine (14), adenosine (15), stigmast-3,6-dione (16), and β-sitosterol-3-O-β-D-glucoside (17). Among the isolated compounds (3, 4, 6, 7-14) are reported for the first time from genus Zygophyllum.

R1

R2

R3

7

COOH

OCH3

H

8

CH=CH-COOH

OCH3

H

9

COOH

H

H

10

CO-CH3

H

H

11

CO-CH3

H

Glc.

12

CO-CH3

OCH3

Glc.

R1

R2

R3

3

CH3

Glc

Glc.

4

CH3

6''-Malonyl Glc.

H

6

H

6''-Malonyl Glc.

H

Acknowledgements: Thanks to the Egyptian Government for the fellowship through The Ministry of Higher Education and Scientific Research.

References: [1] Tackholm V (1974) Students Flora of Egypt, p.307–309. Anglo-Egyptian Bookshop. [2] Dragendorff (1989) Die Heilpflanzen der Verschiede Volker und Zeiten, p.444. Stuttgart.