Inhibitory Effect of Macabarterin, a Polyoxygenated Ellagitannin from Macaranga barteri, on Human Neutrophil Respiratory Burst Activity
An ellagitannin with a 2,4-acyl group, named macabarterin (1), and a new ellagic acid glycoside, 3-O-methylellagic acid 4-O-â-D-xylopyranoside (2), were isolated from the stem bark extract of Macaranga barteri along with five known phenolic compounds, ellagic acid (3) , 3-O-methylellagic acid (4) , gallic acid (5) , methyl gallate (6) , and scopoletin (7) . The structures of 1 and 2, as well as those of the known compounds, were elucidated on the basis of spectroscopic data and by comparison with reported data [1–4]. Compounds 1-5 and 7 were tested for their anti-inflammatory potential in a cell-based respiratory burst assay, compound 1 being found an inhibitor of the superoxides produced in the cellular system.
Acknowledgments: The authors gratefully acknowledge the help of Ms. A. Z. Zaidi for HRESIMS and Dr. R. A. Siddiqui (Methodist Research Institute, Indiana University, Indianapolis, IN) for help in the establishment of the cell-based In vitro respiratory burst inhibitory essay. We also wish to thank „The Academy of Sciences for the developing World (TWAS)“ for financial support through a research grant to R.M.N.
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