Planta Med 2011; 77 - P_23
DOI: 10.1055/s-0031-1273552

Bioactive Perylenequinones from the Plant Pathogenic Fungus Septoria pistaciarum (Ascomycetes)

M Kumarihamy 1, 2, MR Jacob 1, SI Khan 1, 2, BL Tekwani 1, 3, D Ferreira 1, 2, NPD Nanayakkara 1
  • 1National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, Mississippi 38677
  • 2Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677
  • 3Department of Pharmacology,School of Pharmacy, The University of Mississippi, University, Mississippi 38677

The ethyl acetate extract of the fermentation culture broth of Septoria pistaciarum (Ascomycetes) showed good antimalarial and antimicrobial activities. Bioassay-guided fractionation of this extract previously afforded four bioactive pyridone compounds [1]. Further investigation of this extract yielded cercosporin(1), 14-acetylcercosporin (2) and cercosporindiacetate (3). These compounds showed antimalarial, antimicrobial, and antileishmanial activities.

Acknowledgements: This work was supported by in part by US Department of Defense CDMRP grant No. W81XWH-09, NIH, NIAID, Division of AIDS, Grant No. AI 27094 and the United States Department of Agriculture, ARS, Specific Cooperative Agreement No. 58–6408–2-009. The authors sincerely thank Dr. B. Avula for recording the MS spectra, and Ms. M. Wright, Mr. J. Trott and Mr. R. Sahu for biological testing.

References: [1] Kumarihamy M, Fronczek FR, et al. (2010)J Nat Prod, 73: 1250–1253.