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Horm Metab Res 2011; 43(4): 231-235
DOI: 10.1055/s-0031-1271747
Original Basic

© Georg Thieme Verlag KG Stuttgart · New York

Exercise-stimulated GLUT4 Expression is Similar in Normotensive and Hypertensive Rats

A. M. Lehnen1 , N. M. Leguisamo1 , G. H. Pinto1 , 2 , M. Markoski1 , K. De Angelis3 , U. F. Machado4 , B. Schaan1 , 5
  • 1Instituto de Cardiologia do RS/Fundação Universitária de Cardiologia do Rio Grande do Sul, Porto Alegre, Brasil
  • 2Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Brasil
  • 3Laboratório do Movimento Humano, Universidade São Judas Tadeu, São Paulo, Brasil
  • 4Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brasil
  • 5Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil
Further Information

Publication History

received 29.07.2010

accepted after second revision 18.01.2011

Publication Date:
17 February 2011 (online)

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Abstract

The effects of exercise training on systolic blood pressure (BP), insulin sensitivity, and plasma membrane GLUT4 protein content in spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats were compared. 16 SHR and 16 WKY male rats, aged 6 months, were randomized into sedentary and trained (treadmill running, 5 days/week, 60 min/day for 10 weeks) groups (n=8/group). At baseline, SHR had lower insulin sensitivity than WKY rats, however, there were no differences between WKY and SHR GLUT4 expression. The 10-week training reduced BP by ∼19% in SHR, improved insulin sensitivity by ∼24% in SHR, but not in WKY, and increased GLUT4 expression in both animal models. Compared to the sedentary group, there was an increase of GLUT4 in WKY rats by ∼25% in the heart, by ∼23% in the gastrocnemius, and by ∼15% in the fat tissue. Trained SHR presented an increase in GLUT4 of ∼21%, ∼20%, and ∼14%, in the same tissues, respectively. There were no differences between SHR and WKY rats in post-training GLUT4 expression. We conclude that training determined BP and insulin resistance reduction in SHR, and increased GLUT4 expression in both normotensive and hypertensive rats. However, considering the similar rise in GLUT4-induced training in SHR and WKY, it is possible that GLUT4 levels in plasma membrane fraction do not have a pivotal role in the exercise-induced improvement of insulin sensitivity in SHR.

Key words

glucose transporter type 4 - exercise training - insulin resistance - hypertension

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Correspondence

Dra. B. Schaan

Instituto de Cardiologia do Rio

Grande do Sul

Av. Princesa Isabel

395 Santana

90620-001 Porto Alegre

RS Brazil

Phone: +55/51/3230 3600 (3636/3757)

Fax: +55/51/3230 3600 (3757)

Email: beatrizschaan@gmail.com

Email: amlehnen@terra.com.br

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