Planta Med 2011; 77(10): 1044-1047
DOI: 10.1055/s-0030-1270745
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Hepatoprotective and Antioxidant Arylbenzofurans and Flavonoids from the Twigs of Morus mesozygia

Gilbert D. W. F. Kapche1 , Dawe Amadou2 , Pierre Waffo-Teguo3 , Jean H. Donfack4 , Christian D. Fozing2 , Dominique Harakat5 , Angèle N. Tchana4 , Jean M. Mérillon3 , Paul F. Moundipa4 , Bonaventure T. Ngadjui2 , Berhanu M. Abegaz6
  • 1Department of Chemistry, Higher Teachers' Training College, University of Yaoundé I, Yaoundé, Cameroon
  • 2Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon
  • 3GESVAB, EA 3675, UFR Pharmacie; Université Victor Segalen Bordeaux 2, Villenave d'Ornon, France
  • 4Department of Biochemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon
  • 5Institut de Chimie Moléculaire de Reims, Unité Mixte de Recherche 6229, Université de Reims Champagne-Ardenne, UFR Sciences, Reims, France
  • 6Department of Chemistry, Faculty of Science, University of Botswana, Gaborone, Botswana
Further Information

Publication History

received April 12, 2010 revised January 7, 2011

accepted January 15, 2011

Publication Date:
09 February 2011 (online)

Abstract

The chemical investigation of the twigs of Morus mesozygia resulted in the isolation of three new prenylated 2-arylbenzofurans, named moracin KM, LM, and SC (13), nine known 2-arylbenzofurans (412), and two known flavonoids (1314). The structures of the new compounds were established as [2′′,3′′:6,7]-(6-(S)-hydroxymethyl-6-methylpyrano)-2-(3,5-dihydroxyphenyl)benzofuran-5-ol (1), [2′′,3′′:6,7]- (4,7-dihydro-6-methyloxepine)-2-(3-hydroxy-5-methoxyphenyl)benzofuran-5-ol (2), and [2′′,3′′:6,7]-(6,6-dimethylpyrano)-2-(3,5-dihydroxyphenyl)benzofuran (3). One of the new compounds, moracin LM (2), displayed modest antioxidant activity, whereas known compounds 4, 13, and 14 showed significant hepatoprotective and antioxidant activities.

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Dr. Gilbert D. W. F. Kapche

Department of Chemistry
Higher Teachers' Training College
University of Yaoundé I

P. O. Box 47

Yaoundé

Cameroon

Phone: +23 7 77 66 49 73

Fax: +23 7 22 23 53 86

Email: dkapche2002@yahoo.com

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