The Spectrum of Coagulation Abnormalities in Thyroid Disorders

Pier Paolo Vescovi; Emmanuel J Favaloro; Giuseppe Lippi; Massimo Garofano; Martina Montagnana; Franco Manzato; Massimo Franchini

doi:10.1055/s-0030-1270065

Seminars in Thrombosis and Hemostasis, Inhaltsverzeichnis

Semin Thromb Hemost 2011; 37(1): 007-010
DOI: 10.1055/s-0030-1270065

The Spectrum of Coagulation Abnormalities in Thyroid Disorders

Pier Paolo Vescovi¹ , Emmanuel J. Favaloro² , Giuseppe Lippi³ , Massimo Garofano¹ , Martina Montagnana⁴ , Franco Manzato⁵ , Massimo Franchini⁶

¹Divisione di Medicina, Ospedale “Carlo Poma,” Mantova, Italy
²Department of Haematology, Institute of Clinical Pathology and Medical Research (ICPMR), Westmead Hospital, Westmead, Australia
³Unità Operativa di Diagnostica Ematochimica, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy
⁴Istituto di Chimica e Microscopia Clinica, Dipartimento di Scienze Morfologico-Biomediche, Università di Verona, Verona, Italy
⁵Laboratorio di Analisi Chimico-Cliniche, Ospedale “Carlo Poma,” Mantova, Italy
⁶Servizio di Immuno-ematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero-Universitaria di Parma, Parma; Italy

Abstract

ABSTRACT

The hemostatic balance is a complex system where the delicate equilibrium is regulated by several factors including hormones. A variety of endocrine disorders have been reported to be associated with coagulation abnormalities, ranging from mild laboratory changes to clinically relevant thrombotic or bleeding manifestations. In this review, we summarize the current knowledge on the main abnormalities of the coagulation and fibrinolytic systems associated with thyroid dysfunctions. Overall, although mostly based on uncontrolled studies, data in the literature suggest that patients with hyperthyroidism or subclinical hypothyroidism have a hypercoagulative state, whereas patients with overt hypothyroidism have a bleeding tendency.

KEYWORDS

Bleeding - thrombosis - hyperthyroidism - hypothyroidism

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Massimo FranchiniM.D.

Servizio di Immunoematologia e Trasfusione

Azienda Ospedaliero-Universitaria di Parma, Parma, Italy

eMail: mfranchini@ao.pr.it