Isolation and identification of chemical constituents from extract of Luo Han Guo (Fruits of Siraitia grosvenori)

C Wu; B Hoekstra; J McChesney; S Venkataraman

doi:10.1055/s-0030-1265865

Planta Medica, Table of Contents

Isolation and identification of chemical constituents from extract of Luo Han Guo (Fruits of Siraitia grosvenori)

C Wu ¹, B Hoekstra ¹, J McChesney ¹, S Venkataraman ¹

¹ChromaDex, Inc., 2830 Wilderness Place, 80301 Boulder, United States

Abstract

Extracts of Luo Han Guo has been commercially utilized as a sweet component in sugar substitutes [1]. Mogroside V, the major component of the extract, was demonstrated to have a sweetness more than 300 times as high as that of sucrose [2]. This study was performed to investigate and identify the other chemical constituents present in commercial extracts of Luo Han Guo.

Fig.1: Dehydrodiconiferyl Alcohol 4-O-β-Glucopyranoside

Seven compounds were isolated by column chromatography; six of them were identified as Mogroside V, 11-Oxo-mogroside V, Grosmomoside I, Siamenoside I, Mogroside III E, and Dehydrodiconiferyl Alcohol 4-O-β-Glucopyranoside. Dehydrodiconiferyl Alcohol 4-O-β-Glucopyranoside was found for the first time in Luo Han Guo.

References: 1. Li, D. Ikeda, T. Matsuoka, N. Nohara, T. Zhang, H. Sakamoto, T. Nonaka, GI. (2006) Chem Pharm Bull 54:1425–1428.

2. Takemoto, T. Arihara, S. Nakajima, T. Okuhira, M. (1983) Yakugaku zasshi 103:1151–1154.