Planta Med 2010; 76 - P649
DOI: 10.1055/s-0030-1264947

Pharmacological and histological study of Centaurea bruguierana ssp. belangerana on indomethacin-induced peptic ulcer in rats

R Ahmadi 1, A Rajabi 1, M Khanavi 1, G Hassanzadeh 1, R Khademi 1, A Hadjiakhoondi 1, M Sharifzadeh 1
  • 1Tehran University of Medical Sciences, Department of Pharmacognosy, Tehran, Iran, 1417614411 Tehran, Iran, Islamic Republic Of

The species Centaurea bruguierana (DC.) Hand.-Mzt. ssp. belangerana (DC.) Bornm. (CBB) (Asteraceae) [1], namely „Baad-Avard“ in Bushehr province, south of Iran, is used in folk medicine as hypoglycemic in diabetes and remedy for peptic ulcer disorders. The inhibitory effects of total extract and fractions of dried flowering samples of CBB collected from Borazjan, Bushehr Province, Iran on indomethacin-induced peptic ulcer in rats were studied. The 80% EtOH extract and petroleum ether, CHCl3, EtOAc, n-BuOH, and remaining MeOH fractions obtained by solvent-solvent fractionation of dried flowering samples of CBB was investigated for anti-ulcer activity against indomethacin-induced ulcerogenesis in rats. The percentage inhibition for total extract with dose of 100mg/kg (99%) and CHCl3 fraction with dose of 42mg/kg (98.95%) were found to be more prominent (***p<0.001) compared to the reference group (cimetidine 100mg/kg, 87.62% ulcer inhibition). A dramatic decrease in ulcer index was observed following the administration of total extract (100mg/kg, ***p<0.001) and CHCl3 fraction (42mg/kg, ***p<0.001) compared to control group. Pharmacoilogical and histological results of the present study proved that the aerial flowering parts of CBB possess preventive activity against peptic ulcer supporting the folkloric assertion in southern Iranian folk medicine. However, these effects are not limited to this species and previous studies have revealed that some other Centaurea species are active as well [2,3,4].

Acknowledgements:Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences grant number: 6091–33–03–86, Department of Anatomy, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

References: 1. Rechinger, K.H., 1980. Flora Iranica, No. 139b. Akademische Druck-u. Verlagsanstalt, Graz.

2. Yesilada E. et al. (1995). J Ethnopharmacol 39: 31–38.

3. Yesilada E. et al. (2004). J Ethnopharmacol 95: 213–219.

4. Yesilada E. et al. (1995). J Ethnopharmacol 46: 133–152.