Planta Med 2010; 76 - P648
DOI: 10.1055/s-0030-1264946

Antiproliferative effect of Bryonia aspera Stev. ex Ledeb

S Sahranavard 1, S Ghafari 2, H Moazzeni 2, F Naghibi 1
  • 1Traditional medicine and materia medica research center, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Pharmacognosy Department, Vali asr street Tehran, Iran, Islamic Republic Of
  • 2Traditional medicine and materia medica research center, Shahid Beheshti University of Medical Sciences, valiasr street, shams alley, 1516745811 Tehran, Iran, Islamic Republic Of

This study was designed to evaluate antiproliferative effects from the roots of Bryonia aspera Stev. ex Ledeb which is used traditionally in the treatment of gastrointestinal disorders, cardiac disorders and cancer [1]. Methanol, chloroform and petroleum ether fractions were prepared and investigated for antiproliferative activity against MCF7 (human breast adenocarcinoma), HepG2 (human hepatocellular carcinoma), WEHI (mouse fibrosarcoma) and MDBK (normal kidney epithelial cell) cell lines by MTT assay and cisplatin and tamoxifen were used as positive control [2]. All the fractions showed significant antiproliferative activity on MCF7 whereas they were inactive on HepG2 and WEHI cell lines (IC50>50µg/ml). Our study showed that the CHCl3 fraction was the most potent one against the MCF7 cell line. In our previous study, we isolated some triterpene cucurbitane-type compounds from the CHCl3 fraction [3]. Further studies are in progress to evaluate the antiproliferative activity of these pure compounds.

References: 1. Ghorbani A. (2005)J. Ethnopharmacol. 102:58.

2. Carmichael J.et al (1987) Cancer. Res. 47:936–42.

3. Sahranavard S. et al (2010) Planta Med. 76: 1–4.