Evaluation of the diurectic activity of an isolated flavonol of the aqueous extract from Boldoa purpurascens Cav.

Boldoa purpurascens Cav. (1) is a wild species which grows in Latin America and the Caribbean; used in several countries as diuretic for affections of the urine tract. The phenol compounds here are in larger proportion in the bioactive fraction. From the aqueous extract of the leave one flavonoid glycoside (2,3) with group benzodioxalane (4′,5-dihydroxy-6,7-methylendioxyflavonol-3-O-α-L-rhamnopyranosil-(1®2)-β-D-xylopyranoside was isolated. This compound could be related with the attributed effect in the investigation. (4). The new flavonoid was evaluated to discern its effect, for the experiment, male rats were used, Sprague Dawley weighing between 160 y 220g. Assay. In the experimental test doses of 100, 50, 25 12, 6, 3mg/Kg of weight were used, the volume of administration being of 10 mL/Kg; as positive control a solution of Furosemide was used (4mg/Kg) and as negative control, water distilled. The statistical analysis was carried out by the test of Kruskal-Wallis with an interval of trust of 99%. The flavonol; showed significant diuretic effect. The activity of the flavonol was most important than that of the standard reference drug, Furosemide but without modifications in the excretions ions, it allowed to suggest that the compound can be included within the group of diuretic compounds called uncovered acuaretics in 2003. The results of the present investigation indicated that the flavonol isolated of B. purpurascens shows profound diuretic activity

Keywords: Boldoa purpurascens, flavonol glycosides, Furosemide

References: 1. Roig, J. T,(1988). Dictionary of Cuban Common Yams, pp 225–226.

2. Niassy, B.; Um, B. – H, et al, (2004). C. R. Chimie 7, 993–996.

3. Jpn. Kokai Tokkyo Koho,(1988), JP63203682 A2.

4. Magalhães AF, Tozzi AM, et al,(2007) Acad Bras Cienc; 79,351–675.