Planta Med 2010; 76 - P602
DOI: 10.1055/s-0030-1264900

Cartilage regeneration effect of orally administered Zingiber officinale Roscoe against MIA-induced osteoarthritis in rats

S Ganabadi 1, S Fakurazi 1
  • 1Universiti Putra Malaysia, Veterinary Pre-Clinical Sceinces, Dept. Veterinary Pre-Clinical Sciences, Faculty of Veterinary MedicineUniversiti Putra Malaysia, Serdang, 43400 Serdang, Malaysia

Osteoarthritis (OA) is developed when the cartilage that protects the bone is gradually destroyed within the synovial joint [1]. Zingiber officinale Roscoe (ZO) is potential to reduce pain and symptoms caused by OA by suppressing cyclooxygenase, lipooxygenase metabolites, and arachidonic acid [2]. This study compares and quantifies the histopathological changes of cartilage between ZO treated rats and control rats in Monosodium idoacetate (MIA)-induced OA. Rats were treated by administration of the suggested therapies using feeding catheter for 28 days. At day 28, rats were sacrificed. Whole right and left knee joints were dissected, processed, and stained with H&E or Safranin-O. Histopathological scores [3] were quantified. ZO group showed significantly low degeneration of the cartilage and significantly less severity of the subchondral bone compared to control group. This study concluded that oral administration of ZO revealed the curative effects of the extract on cartilage of OA joints.

Acknowledgements: Ministry of Science, Technology and Innovation, Malaysia and Universiti Putra Malaysia.

References: 1. Moreland, LW. (2003). Arthritis Res. Ther. 5:54–67.

2. Tjendraputra, E. et al. (2001). Bioorg. Chem. 29(3):156–163.

3. Kobayashi K. et al. (2003). J. Vet. Med. Sci. 65(11): 1195–1199.