Planta Med 2010; 76 - P488
DOI: 10.1055/s-0030-1264786

Chemical constituents of Glycosmis parva and their anti-herpes simplex virus activities

C Chansriniyom 1, N Ruangrungsi 1, V Lipipun 1, T Kumamoto 2, T Ishikawa 2
  • 1Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pharmacognosy and Pharmaceutical Botany, 254 Phaya Thai Road, Patumwan District, 10330 Bangkok, Thailand
  • 2Graduate School of Pharmaceutical Sciences, Medicinal Organic Chemistry, 1–33, Yayoi-cho, Inage-ku, Chiba-shi, 263–8522 Chiba, Japan

The investigation of EtOAC of branches and leaves of Glycosmis parva Craib [1, 2] (Rutaceae) collected in Thailand led to the isolation of a new acridone alkaloid, glycosparvarine (1), three new sulfur-containing propanamide derivatives, (+)-S-deoxydihydroglyparvin (2), (+)-S-deoxytetrahydroglyparvin (3) [3] and (+)-tetrahydroglyparvin (4), together with nine known compounds (N-methylatalaphylline, N-methylcyclo-atalaphylline-A, glycofolinine, citramine, arborinine, limonin, a mixture of limonexic acid and isolimonexic acid, glyparvin-A and dihydroglyparvin). Antiviral activity evaluation of isolated compounds against herpes simplex virus (HSV) type 1 and 2 disclosed that glycosparvarine (1), (+)-tetrahydroglyparvin (4) and glycofolinine, showed moderate inhibitory activities with EC50 of 348, 229 and 151 µM, respectively. In addition, (+)-S-deoxydihydroglyparvin (2) exhibited activities with EC50 of 29.8 and 44.6 µM against HSV-1 and HSV-2, respectively.

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Acknowledgements: Royal Golden Jubilee (RGJ) Ph.D. program 2004 (PHD/0212/2547), Thailand Research Fund

References: 1. Stone, B. C. (1985) Proc. Acad. Nat. Sci. Phila. 137:1–27.

2. Hofer, O. et al. (1998) Monatsh. Chem. 129: 213–219.

3. Chansriniyom, C. et al. (2009) Chem. Pharm. Bull. 57:1246–1250.