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DOI: 10.1055/s-0030-1264766
In vitro anti-Neisseria gonorrhoeae activity of Terminalia boivinii, Terminalia sambesiaca and Terminalia spinosa
The genus Terminalia (Combretaceae) is known as a source of bioactive secondary metabolites. This work aims at the in vitro activity of leaf and root hydroethanol extracts of Terminalia boivinii Tul., Terminalia sambesiaca Engl. and Diels and Terminalia spinosa Engl. against nine N. gonorrhoeae penicillin and tetracycline sensitive and resistant strains, by means of the agar dilution method. Results showed the activity of all tested samples against the different strains, with minimum inhibitory concentrations (MIC) ranged between 100 and 400µg/ml (Table 1). The leaf extracts of all species are slightly more active than root ones. The establishment of the metabolomic profile of these extracts is ongoing.
N. gonorrhoeae strains |
MIC µg/ml) |
||||
T. boivii |
T. sambesiaca |
T. spinosa |
|||
L |
L |
R |
L |
R |
|
INSA 195 |
200 |
200 |
200 |
200 |
200 |
INSA 219 |
200 |
200 |
400 |
200 |
200 |
INSA 227 |
200 |
200 |
200 |
200 |
400 |
INSA 232 |
200 |
100 |
200 |
100 |
200 |
INSA 249 |
200 |
200 |
200 |
200 |
200 |
INSA 257 |
200 |
100 |
200 |
200 |
200 |
Bilthoven 7391 |
200 |
200 |
200 |
200 |
200 |
CRA/INSA 7567 |
200 |
200 |
200 |
200 |
200 |
ATCC 49226 |
200 |
200 |
200 |
200 |
200 |