In vitro anti-Neisseria gonorrhoeae activity of Terminalia boivinii, Terminalia sambesiaca and Terminalia spinosa

The genus Terminalia (Combretaceae) is known as a source of bioactive secondary metabolites. This work aims at the in vitro activity of leaf and root hydroethanol extracts of Terminalia boivinii Tul., Terminalia sambesiaca Engl. and Diels and Terminalia spinosa Engl. against nine N. gonorrhoeae penicillin and tetracycline sensitive and resistant strains, by means of the agar dilution method. Results showed the activity of all tested samples against the different strains, with minimum inhibitory concentrations (MIC) ranged between 100 and 400µg/ml (Table 1). The leaf extracts of all species are slightly more active than root ones. The establishment of the metabolomic profile of these extracts is ongoing.

Table 1: Anti-N. gonorrhoeae activity of T. boivinii, T. sambesiaca and T. spinosa

N. gonorrhoeae strains	MIC µg/ml)
	T. boivii	T. sambesiaca		T. spinosa
	L	L	R	L	R
INSA 195	200	200	200	200	200
INSA 219	200	200	400	200	200
INSA 227	200	200	200	200	400
INSA 232	200	100	200	100	200
INSA 249	200	200	200	200	200
INSA 257	200	100	200	200	200
Bilthoven 7391	200	200	200	200	200
CRA/INSA 7567	200	200	200	200	200
ATCC 49226	200	200	200	200	200