Planta Med 2010; 76 - P428
DOI: 10.1055/s-0030-1264726

Antitubercular resorcinol analogs and benzenoid C-glucoside from the roots of Ardisia cornudentata

I Chen 1, C Chang 1, H Chang 1, C Peng 1
  • 1Kaohsiung Medical University, Graduate Institute of Natural Products, College of Pharmacy, No.100, Shi-chuan 1st Rd, 807 Kaohsiung, Taiwan

Ardisia cornudentata Mez (Myrsinaceae) is a small shrub, endemic to Taiwan, and distributed at low altitudes in the North and South of the island [1]. The whole plant of this species has been used as folk medicine to eliminate blood stasis, disperse swelling, improve blood circulation, and also as an analgesic [2]. The methanolic extract of the root of this species showed antitubercular activity against Mycobacterium tuberculosis H37RV in vitro. The extract was partitioned into n-hexane, EtOAc, and H2O-soluble layers. The EtOAc-soluble layer showed potent antitubercular activity against M. tuberculosis H37RV in vitro. Bioassay-guided fractionation of the active EtOAc-soluble layer of the roots of A. cornudentata led to the isolation of three new compounds, 3-methoxy-2-methyl-5-pentylphenol (1), 3-methoxy-2-methyl-5-(1′-ketopentyl)phenol (2), and cornudoside (3), together with twenty-six known compounds. Their structures were elucidated by analysis of spectroscopic data. Thirteen of these isolates, 1, 2, 4-6, 9-15 and 21 showed antitubercular activities against M. tuberculosis H37RV in vitro, with MIC values of 2.5–60µg/mL.

Fig.1: Structures of compounds 1-3.

References: 1. Lu SY, Yang YP (1998) Flora of Taiwan, Editorial Committee of the Flora of Taiwan, Taipei.

2. Committee on Chinese Medicine and Pharmacy (2003) The Catalogue of Medicinal Plant Resources in Taiwan, Committee on Chinese Medicine and Pharmacy, Department of Health Executive Yuan, Taipei.