Planta Med 2010; 76 - P401
DOI: 10.1055/s-0030-1264699

New antibiotic metabolites from the fungal endophyte Stemphylium globuliferum isolated from Mentha pulegium

A Debbab 1, A Pretsch 2, R Edrada-Ebel 3, V Wray 4, P Proksch 1
  • 1Institute for Pharmaceutical Biology and Biotechnology, Heinrich-Heine University, Gebäude 26.23., Universitätsstr. 1, 40225 Düsseldorf, Germany
  • 2SeaLife Pharma GmbH, Technopark 1, 3430 Tulln, Austria
  • 3Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, The John Arbuthnott Building, 27 Taylor Street, G4 0NR Glasgow, United Kingdom
  • 4Helmholtz Centre for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany

During our ongoing search for new bioactive metabolites from endophytic fungi with focus on the discovery of new antimicrobial compounds, we investigated the fungal strain Stemphylium globuliferum isolated from the medicinal plant Mentha pulegium (Lamiaceae). The EtOAc extract of the poorly investigated S. globuliferum fungal strain afforded six new bisanthraquinones, together with four known related compounds. All compounds were tested for their antimicrobial activity (including antibacterial, antifungal and antiviral activities). All dimers were found to be highly active at minimal inhibitory concentrations (MIC) of 7–125 µg/mL. Of specific interest is the fact that the alterporriol-type dimers, alterporriol E and its atropisomer D, exhibited different activity patterns against similar pathogenic microorganisms.