Planta Med 2010; 76 - P394
DOI: 10.1055/s-0030-1264692

Phenolic compounds from Lespdesza cuneata

J Kim 1, D Kwon 2, C Si 3, Y Bae 2
  • 1Institute of Natural Medicine, 39 Hallymdaehak-gil, 200702 Chuncheon, Korea, Republic Of
  • 2Forest Biomaterials Engineering, Kangwon national university, 200–702 Chuncheon, Korea, Republic Of
  • 3Tianjin Key Laboratory of Pulp & Paper, P.O. Box 183, No.29at 13th Avenue of TEDA, 300457 Tianjin, China

Phenolic compounds, especially flavonids and its derivatives play an important role in medicine, food addictives and cosmetic materials fabrication and development [1]. As one chain of our continually exploring active and functional flavonoids from plants, aerial parts of Lespdesza cuneata G. Don (Leguminosae) was studied in this work. L. cuneata naturally grows in fields of East and South Asian countries, such as Korea, China, Japan and India [2]. In folk medicines, the aerial parts of L. cuneata have long been used to cure various diseases [3]. However, its chemical constituents are far from fully investigated. The aerial parts of L. cuneata were collected, air-dired and extracted with 95% aqueous ethanol. Then was successively partitioned with n-hexane, chloroform, ethyl acetate and H2O, and freeze dried. Repeat Sephadex LH-20 open column chromatography on a portion of ethyl acetate and aqueous soluble powders resulted in the isolation of four flavone glycosides, and their structures were elucidated as desmodin, homoadonivernith, kaempferol and quercetin based on extensive spectroscopic techniques such as 1H NMR, 13C NMR and Mass spectrum.

Acknowledgements: This work was supported by Priority Research Centers Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2009–0094074), Natural Science Foundation of Tianjin City (09JCYBJC15800) and Foundation for the Development of Science and Technology in Tianjin Universities (No. 20080616).

References: 1. Si, CL. et al. (2009) Planta Med. 75:1165–1167.

2. Lee CH. (1994) The pharmacology of Chinese Herbs, CRC Press, China.

3. Ding, JL. et al. (2006) Korean J. Biotechnol. Bioeng. 21:414–419.