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Studies on the chemical constituents and their biological activities of the fruit of Garcinia multiflora
Garcinia multiflora (Champ.) is a small evergreen tree of the Guttiferae family, distributed in South China, Hong Kong, and Taiwan . Xanthones, flavonoids, benzophenones, and their derivatives are widely distributed in plants of the genus Garcinia. Many of these compounds exhibit cytotoxic, anti-inflammatory and antitubercular activities. In our studies on the anti-inflammatory constituents of Formosan plants, many species have been screened for in vitro anti-inflammatory activity, and G. multiflora has been found to be one of the active species. Six new benzophenone derivatives, 13,14-didehydoxyisogarcinol (1), garcimultiflorone A (2), garcimultiflorone B (3), 13-hydroxy-garcimultiflorone B (4), garcimultiflorone C (5), and garcimultiflorone D (6), together with eleven known compounds (7–17) have been isolated and identified from the fruit of G. multiflora. The structures of these new compounds were determined through spectral analyses including extensive 2D NMR. Among the isolates, garcimultiflorone B (3) exhibited potent inhibition with IC50 values of 0.11±0.04 and 0.14±0.02µM, respectively, against fMLP/CB-induced superoxide anion generation and elastase release. In addition, δ-tocotrienol (10) showed the antitubercular activity with MIC value of 30.0µM against Mycobacterium tuberculosis H37Rv in vitro.
Acknowledgements: This work was supported by grant from the National Science Council of the Republic of China.
References: 1. Chang, C.E., Hartley, T.G. (1993) Guttiferae in Flora of Taiwan. 2nd edition. Editorial Committee of the Flora of Taiwan, Taipei, Taiwan 2: 694–714