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Cladieunicellins A and B, two new eunicellin-based diterpenoids from an Indonesian octocoral Cladiella sp.
Two novel eunicellin-based diterpenoids, designated as cladieunicellins A (1) and B (2), were obtained from an Indonesian octocoral identified as Cladiella sp. The structures of eunicellins 1 and 2 were established by spectroscopic methods. These two compounds are the first metabolites of eunicellin-related natural products found to possess 2-hydroxybutanoxy groups. Eunicellin 1 exhibited significant cytotoxicity toward CCRF-CEM tumor cells (ED50=3.61µg/ml) and moderate cytotoxicity towards DLD-1 (ED50 =8.50µg/ml) and P388D1 (ED50=8.32 µg/ml) tumor cells. Eunicellin 2 was also found to exhibit moderate cytotoxicity towards CCRF-CEM (ED50=4.65µg/ml) and DLD-1 (ED50=10.15µg/ml) tumor cells.