Planta Med 2010; 76 - P340
DOI: 10.1055/s-0030-1264638

Effects of pear alcoholic fermentation beverage on airway hyperresponsiveness and immunoglobulin production in asthmatic mice

H Kim 1, C Lim 2, S Cho 1
  • 1School of Korean medicine Pusan National University, Herbology, mulgeum eup, 626770 Yangsan, Korea, Republic Of
  • 2Dongguk University, Department of Medicine, Graduate School, Dongguk University, 410–773 gyeonggi-do, Korea, Republic Of

Objective: To investigate the inhibitory activity of alcoholic fermentation beverage using pear, Bae Ro Mi In (BRMI), in asthma, we evaluated the airway hyperresponsiveness and immunoglobulin production in asthmatic mouse model.

Methods: The airway hyperresponsiveness was measured by enhanced pause (Penh). Antigen specific total antibody and subclasses such as IgG1, IgG2a and IgE were measured by ELISA. Prednisolone (PD, 5mg/kg) was used as positive control.

Results: Oral administration of BRMI did not attenuate airway hyperresponsiveness. But, production level of OVA-specific total antibody significantly decreased by BRMI. Especially, BRMI suppressed the OVA-induced serum IgE level compared to non-treated control group. PD decreased airway hyperresponsiveness and production levels of total antibody and IgE in serum respectively.

Fig.1: Effects of BRMI on OVA-specific IgE production in serum. Amount of OVA-specific IgE was measured using ELISA method. NOR: naive group, CTL: asthma induced control group, BRMI: BRMI administered group PD: prednisolone administered group. N.D.: not detectable. Results are presented as mean±SD. *P<0.05, **P<0.01 as compared with control group. (n=8)

Conclusion: These findings demonstrate that BRMI could be decreased levels of OVA-specific total antibody and IgE production in asthmatic mice. BRMI likely exerts its preventive or cure effect through regulation of antigen-specific antibody production in asthma.

Key words: Pear beverage, asthma, immunoglobulin