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Effects of pear alcoholic fermentation beverage on airway hyperresponsiveness and immunoglobulin production in asthmatic mice
Objective: To investigate the inhibitory activity of alcoholic fermentation beverage using pear, Bae Ro Mi In (BRMI), in asthma, we evaluated the airway hyperresponsiveness and immunoglobulin production in asthmatic mouse model.
Methods: The airway hyperresponsiveness was measured by enhanced pause (Penh). Antigen specific total antibody and subclasses such as IgG1, IgG2a and IgE were measured by ELISA. Prednisolone (PD, 5mg/kg) was used as positive control.
Results: Oral administration of BRMI did not attenuate airway hyperresponsiveness. But, production level of OVA-specific total antibody significantly decreased by BRMI. Especially, BRMI suppressed the OVA-induced serum IgE level compared to non-treated control group. PD decreased airway hyperresponsiveness and production levels of total antibody and IgE in serum respectively.
Conclusion: These findings demonstrate that BRMI could be decreased levels of OVA-specific total antibody and IgE production in asthmatic mice. BRMI likely exerts its preventive or cure effect through regulation of antigen-specific antibody production in asthma.
Key words: Pear beverage, asthma, immunoglobulin