Planta Med 2010; 76 - P332
DOI: 10.1055/s-0030-1264630

New clerodane diterpenoids from Salvia adenophora Fernald (Lamiaceae)

A Bisio 1, G Damonte 2, D Fraternale 3, E Giacomelli 1, A Salis 2, E Russo 1, S Cafaggi 1, D Ricci 3, G Romussi 1, N DeTommasi 4
  • 1University of Genoa, Dept. of of Chemistry and Pharmaceutical and Food Technologies, Via Brigata Salerno 13, 16147 Genova, Italy
  • 2University of Genova, Dept. of Experimental Medicine and Center of Excellence for Biomedical Research, Viale Benedetto XV, 7, 16132 Genova, Italy
  • 3University of Urbino, Dipartimento di Scienze dellUomo, dellAmbiente e della Natura, Via Bramante 28, 61029 Urbino, Italy
  • 4University of Salerno, Dipartimento di Scienze Farmaceutiche, Via Ponte Don Melillo, 84084 Salerno, Italy

The surface exudate of the aerial parts of S. adenophora [1], that showed germination total inhibition [2] against Papaver rhoeas L. and Avena sativa L. at 5mg/L in Petri dish experiments, subjected to column chromatography on Sephadex LH-20 and silica gel and to HPLC-MS and MS2 experiments followed by semi-preparative RP-HPLC, yielded two new clerodane diterpenoids (1 and 2), identified by IR and NMR analysis, including TOCSY, COSY, HSQC, HMBC and ROESY experiments, ESI-TRAP-MS and HR-MS analysis.


References: 1. Epling, C. (1940) A Revision of Salvia, subgenus Calosphace. In: Repertorium Specierum Novarum Regni Vegetabilis. Vol. 110. Fedde F., University of California Press: Berkley, California.

2. Chiapusio. G., Sanchez A.M., Reigosa M.J., Gonzalez L., Pellissier F. (1997), Journal of Chemical Ecology, 23, 2445–2453.