Planta Med 2010; 76 - P279
DOI: 10.1055/s-0030-1264577

New monographs proposed for the German homeopathic pharmacopoeia (HAB) for the manufacture of starting materials from bacteria, yeast and fungi

G Bader 1, A Akkoyun 1, K Wiethoff 1
  • 1Sanum-Kehlbeck GmbH & Co. KG, Regulatory Affairs, Hasseler Steinweg 9, 27318 Hoya (Weser), Germany

Fermentation cultures of yeasts (e.g. Candida albicans, C. parapsilosis), fungi (e.g. Aspergillus niger, Mucor mucedo M. racemosus, Penicillium brevicompactum, P. chrysogenum, P. glabrum, P. roquefortii, Fomitopsis pinicola) and bacteria (e.g. Bacillus subtilis, Mycobacterium phlei, Staphylococcus aureus, Streptococcus pyogenes) after preparation were used as active substances (D3, D4, D5 or D6) in different isopathic drug products (drops, injections, tablets, capsules, suppositories and ointments). Isopathy is a special kind of homeopathy [1]. According to isopathic experience during the last 30 years, these drug products were used in the adjuvant treatment of various disorders according to the symptom picture of homeopathic medicine without any severe adverse effects. Possible immunotoxic effects after repeated oral, rectal or subcutaneous application were tested in various guideline studies with GLP compliance in BALB/c mice and Dunkin-Hartley guinea pigs. In general, it can be concluded that the above applications of D3 to D6 dilutions can be regarded as safe. Three valid manufacturing processes are proposed for the German Homeopathic Pharmacopoeia [2]. Preparations according to method A [3] are prepared from cultures of bacteria, yeasts or fungi as well as the fruit bodies of higher fungi. Preparations according to method B [4] are produced from bacteria, yeasts or fungi cultures after acidic or alkaline extraction. Secreted metabolic products of bacteria, yeasts or fungi are prepared by method C [5]. Lyophilisates are identified by capillary electrophoresis (CE), SDS-polyacrylamide gel electrophoresis (SDS-PAGE) or high performance anion exchange chromatography (HPAEC).

References: 1. Kracke, A., Wiethoff, K. Isopathie – Eine besondere Therapieform, Report Naturheilkunde (in press).

2. German Homeopathic Pharmacopoeia (HAB) draft monograph „H 5.2.6 Isopathics“.

3. German Homeopathic Pharmacopoeia (HAB) draft monograph „Prescription A: Mother tinctures made of bacteria fungi or yeasts (isopathics)“.

4. German Homeopathic Pharmacopoeia (HAB) draft monograph „Prescription B: Mother tinctures made of bacteria fungi or yeasts after acidic or alkaline extraction (isopathics)“.

5. German Homeopathic Pharmacopoeia (HAB) draft monograph „Prescription C: Mother tinctures made of secreted metabolic products of bacteria fungi or yeasts (isopathics)“.