Ligusticum mutellina (L.) Crantz: a pharmacognostic overview
Mountain lovage represents the plant Ligusticum mutellina (L.) Crantz or Meum mutellina (L.) Gaert, Apiaceae. It naturally grows in alpine areas, and is known as an antitumoral ethnobotanic remedy. Also, the roots are used in the production of a type of Schnapps in Bayern, Germany . The present study consists of an analysis of some pharmacognostic parameters describing the aerial part of the plant, harvested from mountains in northern Serbia. Polyphenolic compounds were determined in the methanolic extract performing HPLC MS analysis. Microelements and heavy metals were quantified through the SAA technique [2,3]. The antimicrobial activity of an ethanolic extract was estimated and an evaluation of the antiproliferative potential was done by the phytobiologic test on Lepidium sativum. Effects on the angiogenic process were determined by performing the chick chorioallantoic membrane assay . 6 polyphenolic structures were revealed in the nonhydrolyzed sample; rutoside was found in high concentration (79.23ug/ml). In the hydrolyzed sample 4 polypheolic compounds were evidenced with quercetin being the most concentrated compound (13.83ug/ml). The vegetal product is in conformity with the official quality parameters concerning the content of heavy metals. The ethanolic extract proved to be active on the selected bacterial cultures. The aqueous extracts in concentrations between 0,35% and 6% expressed an inhibitory effect of 70–89%. The CAM assay showed possible antiangiogenic activity, dependent on the concentration of the extractive solution. The results obtained indicate an antimicrobial and a possible antiproliferative effect of different extracts of Ligusticum mutellina (L.) Crantz.
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