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New labdane-type diterpenes and antitubercular constituents from Hedychium coronarium
Hedychium coronarium Koenig (Zingiberaceae) is a perennial rhizomatous herb, distributed in India, Malaysia, Vietnam, southern China, and Taiwan . Various labdane-type diterpenes are widely distributed in plants of the genus Hedychium. Many of these compounds exhibit cytotoxic, anti-inflammatory, and hepatoprotective activities and show inhibitory effects on the increase in vascular permeability, NO production, and iNOS induction. Two new labdane-type diterpenes, hedychicoronarin A (1) and hedychicoronarin B (2), and ten known compounds (3-12) have been isolated and identified from the rhizome of Hedychium coronarium. The structures of new compounds 1 and 2 were determined through spectral analyses including extensive 2D NMR data. Among the isolated compounds, (+)-coronarin A (3) and coronarin D methyl ether (4) exhibited antitubercular activities with MICs=80 and 50µg/mL, respectively, against Mycobacterium tuberculosis H37Rv in vitro. The structural elucidation of new compounds 1 and 2 and the antitubercular activities of the isolates will be discussed in this symposium.
References: 1. Wang, J.C. et al. (2000) Zingiberaceae in Flora of Taiwan, 2nd edition. Taipei: Editorial Committee of the Flora of Taiwan; Vol. 5: 707–724.