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DOI: 10.1055/s-0030-1264508
Microbial contamination of commercial samples of Matricariae flos from Romania
Our research was focused on the assessment of pharmaceutical quality of 9 commercial samples (C1-C9) of Chamomillae flos marketed by Romanian pharmacies and one control sample (C0) exclusively produced by Sidroga for the pharmaceutical network. For a complete image of the quality we analyzed the samples in accordance to the requirements of the 5th European Pharmacopoeia [1] (in force at the time the products were marketed) including the microbial contamination. The contaminants are presentted in the table below.
Samples |
||||||||||
Microbial strains |
C0 |
C1 |
C2 |
C3 |
C4 |
C5 |
C6 |
C7 |
C8 |
C9 |
Escherichia coli |
– |
– |
+ |
– |
– |
– |
– |
– |
– |
– |
Moulds |
– |
Aspergillus sp. |
– |
Aspergillus niger, Rhyzops nigricans, Mucor mucedo, M. racemosus, Penicilium sp. |
– |
– |
Penicilium sp. |
– |
– |
– |
Yeasts |
+ |
+ |
+ |
+ |
+ |
+ |
+ |
+ |
+ |
+ |
TMC (CFU/g) |
2000 |
1500 |
5000 |
2000 |
5800 |
6300 |
2800 |
3000 |
9800 |
1200 |
All in all, TMC (total microbial count) values for all samples were within the imposed limits, but compared to actual European Pharmacopoeia [2] 80% of the chamomile samples would not comply regarding the TYMC (total yeast and mould count).
References: 1. European Pharmacopoeia, 5th ed., EDQM, Strasbourg.
2. European Pharmacopoeia, 6th ed., EDQM, Strasbourg.