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New bioactive compounds from Derris malaccensis, Carissa carandas and Carissa spinarum
Derris malaccensis roots have been used locally as insecticide  whereas the stems of Carissa carandas and C. spinarum each have been used as bitter tonic . In this study, these plants were subjected to chemical and biological investigations. Chromatographic separation of the extracts prepared from Derris malaccensis roots, Carissa carandas stems and C. spinarum stems led to the isolation of three new and eighteen known compounds. The structures of the isolates were determined on the basis of spectroscopic evidence (mainly NMR and MS). These compounds were then examined for their antioxidative property, antiherpetic potential and cytotoxicity. The structures of the new compounds were established as 6-oxo-dehydroelliptone (1), carandoside (2) and (6S,7R,8R)-7a-[(β-glucopyranosyl)oxy]lyoniresinol (3). Several of the isolated compounds showed interesting antioxidative activity, antiherpetic potential and cytotoxicity.
Acknowledgements: The Thailand Research Fund for a 2005 Royal Golden Jubilee Scholarship, The 90th Anniversary Chulalongkorn University (Ratchadaphiseksomphot) Endowment Fund
References: 1. Thasana, N. et al. (2001) Heterocycles 55:1121–1125.
2. Faculty of Pharmaceutical Sciences, Mahidol University (1995) Siam Medicinal Plants: National Wisdom. Amarin Printing and Publishing. Bangkok.